Joe Biden and Paul Ryan are set to debate for the first and last time about domestic and foreign policy.
The 90-minute debate will take place at Centre College in Danville, Kentucky, the same setting as the 2000 Vice Presidential Debate with Dick Cheney and Joe Lieberman.
The Commission on Presidential Debates (CPD) selected ABC News' Martha Raddatz to moderate tonight's festivities. Prior moderating experience for Raddatz includes a debate featuring Ted Kennedy when she reported in Boston.
Leading up to the first presidential debate, the CPD allowed moderator Jim Lehrer to select the topics and it was revealed to the public days ahead of the debate, however, the same has not been done for the vice presidential debate.
It is not clear if the CPD also gave Raddatz the option to select the topics for tonight's debate, but all that is confirmed is the questions will be based on domestic and foreign policy.
The first presidential debate focused on domestic policy, and the third presidential debate later this month will be on foreign policy, therefore tonight's debate will have a lot to cover in 90 minutes.
The format for the vice presidential debate will be similar to the first presidential debate. The debate will have nine questions, the candidates will have two minutes to respond, followed by a 10 minute back and forth discussion.
Although the topics have not been confirmed, what are likely to be brought up are health care, the economy, the Middle East, and the death of US Ambassador Christopher Stevens.
"I'd be surprised if there weren't far more fireworks in this debate than there were in the first presidential debate," said University of Maine political science professor Mark Brewer to Reuters.
As Reuters noted, "Ryan built his reputation on a proposal that would partially privatize the government-run medical plan for the elderly and handicapped in an effort to prevent health costs from swamping the federal budget. Democrats say the plan would force retirees to pay thousands of dollars more for medical treatment."
Biden will have to defend and promote the positives of "Obamacare."
As for the Middle East and situation in Libya, the advantage go for in favor for Biden as he previously served as chair of the Senate Foreign Relations Committee, the same committee that handled the Obama's troop withdrawal from Iraq.
Ryan will have to promote Romney's recent stance on foreign policy and call Obama's foreign policies as a "failure," as Romney stated during a speech on Monday at the Virginia Military Institute.
The economy will go back and forth as both campaigns accuse each other of either raising or cutting taxes that will hurt the middle class and the role of regulating the banks that were deemed as "too big to fail."
Meanwhile, the American Civil Liberties Union (ACLU) are asking supporters to sign a petition to have Raddatz ask about a woman's right to choose.
ACLU stated, "The presidential candidates debated domestic issues for 90 minutes last week and not a word was spoken about a woman's right to choose, access to contraception or federal funding for family planning services. This happened even though the war on women and its consequences have had devastating consequences for millions of women all across America."
They added, "Tell debate moderator Martha Raddatz: Make sure access to abortion and contraception aren't ignored in the Vice Presidential debate."
The debate starts at 9 p.m. EDT, live.
Latinos Post will have a timeline of the debate at 10:40 p.m. EDT.
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