Thursday Night Football
The Tampa Bay Buccaneers, who may be without star running back Doug Martin for the rest of the year, attempt to get their first win of the season against Cam Newton and the Carolina Panthers, who are looking to go above-.500 for the first time since 2008.
The Seattle Seahawks try to extend their NFC West lead on "Thursday Night Football" as they travel to Arizona to take on the Cardinals, looking to keep pace with the division leader.
Jay Cutler and the Chicago Bears are looking to turn things around after losing their last two games at the expense of Eli Manning and the winless New York Giants on "Thursday Night Football".
The Cleveland Browns are 2-0 after their surprising trade of RB Trent Richardson, looking to extend their winning ways against rookie Buffalo Bills' QB EJ Manuel, who is coming off a Week 4 victory over the defending Super Bowl champion Baltimore Ravens.
The San Francisco 49ers, a favorite to reach the Super Bowl this year, have sputtered out of the gate and hope rebound against the St. Louis Rams, who hope to build on last year's success against the 49ers.
Joe Flacco and the Ravens begin their defense of their Super Bowl championship against Peyton Manning's no-huddle, high-octane offense.